| Regional Biophysics Meeting 2005, March 16-20, Zreče, Slovenia | [ComputModel] |
It was shown in 1992 by Peng et al.[1] that nucleotide - nucleotide correlations in the DNA sequences can be described by inverse power law. We have shown that in specific cases the correlation functions decay exponentially[2]. At the moment several entire genomes are completed or being close to completion and long enough nucleotide sequence contigs are available for the analyses. In addition to the standard nucleotide sequences there is also abundant information available regarding the sequence polymorphysms in the populations. We have analysed the distribution of single nucleotide polymorphysm sites (snp) distributed along all 24 human human chromosomes. The positional correlation functions were evaluated for the snp sites and also cross correlation functions were evaluated for snps with regard to several other sequential elements such as SINE and LINE elements. [1] C.-K. Peng, S. V. Buldyrev, A. L. Goldberger, S. Havlin, F. Sciortino, M. Simons and H. E. Stanley, Nature, 356 (1992) 168. [2] B. Borstnik, D. Pumpernik and D. Lukman, Europhys. Lett., 23 (1993) 389.
Email: borut.oblak@cmm.ki.si
Address: National Institute of Chemistry, L1, Hajdrihova 19, 1000 Ljubljana, Slovenia