| Regional Biophysics Meeting 2005, March 16-20, Zreče, Slovenia | [CellBiophys] |
Abstract A mathematical model of a force development in smooth muscles is presented in this paper. The starting point of our work is the calcium dependent latch bridge model published by Hai and Murphy (Am.J. Physiol. 255:C86 – C106, 1988). This model takes into account four different states of cross bridges and can clearly demonstrate that latch bridges maintain the stress in muscles that has been developed by the phosphorylated cross bridges. On the other hand, it is widely accepted that a force in muscles is generated during the transition between two states of weakly and the strongly bound cross bridges. If this was true then the latch bridge model would not allow a detailed study of the force development in muscles because the two states have not been taken explicitly into consideration. Therefore we have expanded this model by including different binding activities of cross bridges. In order to predict the muscle force, a calcium transient is simulated for two different values of the characteristic transient time, the first one of a calcium pulse in cytosolic oscillations of about several seconds and the other one of about 40 minutes. We are analysing and comparing the predictions of both models.
Email: andrej.dobovisek@uni-mb.si
Address: University of Maribor, Faculty of Education, Koroška cesta 160, Maribor, Slovenija