| Regional Biophysics Meeting 2005, March 16-20, Zreče, Slovenia | [ComputModel] |
The study was focused to dissolution of non-occlusive blood clots, i.e., the clots that only partially fill blood vessels and have a channel through which blood flows at usually much higher velocities than normally. Our aim was to show experimentally by magnetic resonance (MR) microscopy of dissolving clots and also by mathematical modeling that fast flowing blood thought the channel has large effect on increase of clot dissolution rate compared to the rate at absence of flow. Blood flow through the channel increases transport of dissolution agents to the clot and also produces large forces to the surface of the clot in the channel. These forces are of a viscous nature when flow is slow (laminar) and may become of a cinematic origin when flow is fast (turbulent). We proposed two models for clot dissolution. Laminar blood flow model predicts clot dissolution rate proportional to the average blood velocity squared, whereas turbulent flow model predicts clot dissolution rate proportional to the third power of the average blood velocity. In experiments, clots in artificial blood flow system were dissolved by rt-PA agent and dynamical imaged by MR microscopy. The two proposed mathematical models fit very well to measured clot cross-section areas.
Email: igor.sersa@ijs.si
Address: Igor Serša,, Jožef Stefan Institute,, Jamova 39,, 1000 Ljubljana, Slovenia